K-26, a novel inhibitor of angiotensin I converting enzyme produced by an actinomycete K-26.
نویسندگان
چکیده
A novel inhibitor of angiotensin I converting enzyme (ACE), designated K-26, was isolated from the broth filtrate of an actiomycete K-26. K-26 is a water soluble, acidic peptide composed of an equal mol of L-isoleucine, L-tyrosine and 1(R)-1-amino-2-(4-hydroxyphenyl)-ethylphosphonic acid. The IC50 of K-26 for ACE inhibition was 6.7 ng/ml when hippuryl-L-histidyl-L-leucine was used as a substrate of ACE. K-26 possesses hypotensive activity in vivo.
منابع مشابه
Crystal structure of a peptidyl‐dipeptidase K‐26‐DCP from Actinomycete in complex with its natural inhibitor
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عنوان ژورنال:
- The Journal of antibiotics
دوره 39 1 شماره
صفحات -
تاریخ انتشار 1986